Updated: Jun 02, 2025

Weight loss pens, also called weight loss injectables, have become a popular tool for people struggling to lose weight. These medications can help curb appetite, regulate blood sugar, and support steady weight loss—but they aren’t magic fixes. Like any treatment, they work best when combined with healthy habits and medical guidance.

Why People Are Turning to Weight Loss Injections

Losing weight isn’t easy—especially if you’ve tried diets, exercise plans, or supplements without results. For some people, biology makes it harder to manage hunger, store fat, or process blood sugar. That’s where injectable medications can help.

Weight loss pens are designed to support long-term weight loss by working with your body’s natural systems. Many were originally developed to treat type 2 diabetes but were later approved for weight loss when studies showed they helped people lose a significant amount of weight safely.

These medications are often prescribed to people with a body mass index (BMI) of 30 or higher, or a BMI of 27+ with a weight-related condition like high blood pressure or diabetes.

What Are Weight Loss Pens?

Weight loss pens are pre-filled injectors that you use to give yourself a small dose of medication once a day or once a week. Most are injected into the stomach, thigh, or upper arm using a very fine needle that feels more like a pinch than a shot.

The most common types of weight loss injectables include:

Semaglutide (Wegovy, Ozempic)
Originally approved for diabetes as Ozempic, semaglutide is also sold as Wegovy for weight loss. It works by mimicking a hormone that helps control appetite and slows down digestion, so you feel fuller longer.

Liraglutide (Saxenda)
This is another daily injection that helps reduce hunger and increase feelings of fullness. It’s often used in people who haven’t had success with diet and exercise alone.

Tirzepatide (Mounjaro)
Approved for diabetes, but also showing strong weight loss results in studies. Some doctors prescribe it “off-label” for weight loss.

These medications are part of a group called GLP-1 receptor agonists. They help regulate how your body handles insulin and blood sugar, which can also help with cravings and energy use.

How They Help with Weight Loss

These injections don’t burn fat directly—but they do make it easier to eat less and stick to healthy habits. Here’s how:

• They slow digestion, so food stays in your stomach longer

• They signal your brain that you’re full sooner

• They help stabilize blood sugar levels, which reduces cravings

• They may even help lower inflammation and improve metabolism

People using these medications, along with diet and exercise, often lose 5–15% of their body weight over several months. That can make a big difference in blood pressure, cholesterol, joint pain, and overall health.

What to Expect

Most people start with a low dose and slowly increase over several weeks. This helps your body adjust and lowers the chance of side effects.

You’ll still need to eat balanced meals, drink water, and stay active. These medications work best when you pair them with consistent, healthy habits.

Some people lose weight quickly in the first few weeks, while others notice a slow and steady drop. The key is to stay patient and stay in touch with your healthcare provider for regular check-ins.

Common Side Effects

Like all medications, weight loss pens can cause side effects. The most common include:

• Nausea

• Constipation or diarrhea

• Headache

• Fatigue

• Bloating or gas

These usually get better as your body adjusts. Eating smaller meals, avoiding greasy foods, and staying hydrated can help.

More serious but rare side effects include:

• Gallbladder issues

• Pancreatitis

• Low blood sugar (especially if you have diabetes)

• Allergic reactions

If you have a history of certain conditions, like thyroid cancer or pancreatitis, your doctor may recommend a different option.

Who Should (and Shouldn’t) Use Them

Weight loss injections are not for everyone. They’re typically prescribed for adults with obesity or weight-related health problems who haven’t had success with other methods.

They may not be safe if you:

• Have a personal or family history of certain thyroid cancers

• Have had pancreatitis

• Are pregnant or breastfeeding

• Have certain stomach or gut disorders

Always talk to your doctor before starting any injectable medication. They’ll review your health history, check your labs, and help decide if it’s a safe choice.

How to Get Weight Loss Injections

Start by talking to your primary care doctor or a weight management clinic. Some community health centers also offer obesity treatment programs that include access to medications.

If you don’t have insurance or have trouble affording medication, look into:

• Manufacturer savings cards or patient assistance programs (offered by drugmakers)

• Prescription discount sites like GoodRx

• Community health clinics with sliding-scale fees

• Telehealth services that specialize in weight care

Programs like Sequence, Plenity, or Ro offer virtual care and prescriptions, often with lower costs and discreet delivery.

Some of these medications can cost over $1,000 per month without insurance, but discounts or insurance coverage can bring the cost down significantly. Always ask about financial assistance options if cost is a concern.

Are They a Long-Term Solution?

Weight loss injections are often used for several months—or even longer—as part of a bigger lifestyle change. Some people stay on them for a year or more, especially if they regain weight when stopping.

These aren’t quick fixes. They’re tools to help you build and maintain healthier habits over time. For best results, combine them with:

• Portion control

• Regular movement (even walks count!)

• More water, less soda

• Better sleep and stress management

Your doctor will help you decide how long to stay on the medication and what to expect when you stop.

Final Thoughts

Weight loss pens can be powerful tools for people who are struggling to lose weight through diet and exercise alone. When used safely under medical guidance, they can help reduce hunger, support healthier habits, and improve your overall well-being. If you’re curious about injectables, start by having a conversation with your doctor—they can help you decide if it’s the right step for you.